Susan M. Gasser

Cabianca, D.S., Munoz Jimenez, C., Kalck, V., Gaidatzis, D., Padeken, J., Seeber, A., Askjaer, P. and Gasser, S.M. (2019) Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei.
Nature, 569, 734-739.

Delaney, CE, Methot, SP, Guidi, M, Katic, I, Gasser, SM, Padeken, J. (2019) Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65.
J Cell Biol. 218(3), 820-838

Padeken, J., Zeller, P., Towbin, B., Katic, I., Kalck, V. and Gasser, S.M (2019) Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression.
Genes Dev. 33(7-8), 436-451. doi: 10.1101/gad.322495.118

Marcomini, I., Shimada, K., Delgoshaie, N., Yamamoto, I., Seeber, A., Horigome, C., Naumann, U. and Gasser, S.M. (2018) Asymmetric processing of DNA ends at double-strand breaks leads to unconstrained dynamics and ectopic translocation.
Cell Reports, 24(10), 2614-2628.e4. doi: 10.1016/j.celrep.2018.07.102

Deshpande, I., Seeber, A., Shimada, K., Keusch, J.J., Gut, H., and Gasser, S.M. (2017) Structural basis of Mec1-Ddc2-RPA assembly and activation on single-strand DNA at sites of damage.
Molecular Cell, 68, 431 - 445

Amitai, A., Seeber, A., Gasser, S.M.* and Holcman, D. (2017) Visualization of chromatin decompaction and break site extrusion as predicted by statistical polymer modeling of single locus trajectories.
Cell Reports, 18, 1200-1214
* Lead author

Hauer, M.H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. and Gasser, S.M (2017) Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates.
Nature Struct. Mol. Biology, doi: 10.1038/nsmb.3347

Seeber, A., Hegnauer, A.M., Hustedt, N., Deshpande, I., Poli, J., Eglinger, J., Pasero, P., Gut, H., Shinohara, M., Hopfner, K-P., Shimada, K. and Gasser, S.M. (2016) RPA-mediated recruitment of MRX to forks and double-strand breaks holds sister chromatids together.
Molecular Cell, 64, 951 - 966. doi: 10.1016/j.molcel.2016.10.032

Zeller, P., Padeken, J., van Schendel, R., Kalck, V., Tijsterman, M. and Gasser, S.M. (2016) Histone H3K9 methylation is dispensable for C. elegans development, but suppresses RNA-DNA hybrid-associated repeat instability.
Nature Genetics, 48, 1385 - 1395. doi: 10.1038/ng.3672

Horigome, C., Bustard, D., Marcomini, I., Tsai-Pflugfelder, M., Cobb, J.A. and Gasser, S.M. (2016) PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.
Genes & Dev. 30, 931-945

Poli, J., Gerhold, C.-B., Tosi, A., Hustedt, N., Seeber, A., Sack, R., Herzog, F., Pasero, P., Shimada, K., Hopfner, K-P. and Gasser, S.M. (2016) Mec1, INO80 and the PAF1 complex cooperate to limit transcription-replication conflicts through RNAPII removal during replication stress.
Genes & Dev. 30, 337-354

Gonzalez-Sandoval, A., Towbin, B.D., Kalck, V., Cabianca, D.S., Gaidatzis, D.,Hauer, M.H., Geng, L., Wang, L., Yang, T., Wang,. X., Zhao, K. and Gasser, S.M. (2015) Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans embryos..
Cell, 163, 1333-1347

Hustedt H, Seeber A, Sack R, Bhupinder B, Vlaming H, van Leeuwen F, Guenole A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM (2015) Yeast PP4 interacts with ATR homologue Ddc2-Mec1 and regulates checkpoint signaling.
Mol Cell. 55:273-289

Towbin BD, Gonzalez-Aguilera C, Sack R, Gaidatzis D, Kalck V, Meister P, Askjaer P, Gasser SM (2012) Step-wise methylation of histone H3K9 positions chromosome arms at the nuclear periphery in C. elegans embryos.
Cell. 150:934-947

Dion V, Kalck V, Horigome C, Towbin BD, Gasser SM (2012) Increased dynamics of double strand breaks requires Mec1, Rad9 and the homologous recombination machinery.
Nat Cell Biol. 14:502-509

Taddei A, Van Houwe G, Hediger F, Kalck V, Cubizolles F, Schober H, Gasser SM (2006) Nuclear pore association confers optimal expression levels for an inducible yeast gene.
Nature 441:774-778

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