A novel pathway ensuring chromosome stability in early mice embryo
The Peters group studies chromatin formation and regulation in mammalian germ cells and during early embryonic development. Now researchers from the group identified a novel pathway that is essential for maintaining the integrity of heterochromatin, and therefore for securing chromosome stability.
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The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.
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SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin.
LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay.
A Nuclear RNA Degradation Pathway Helps Silence Polycomb/H3K27me3-Marked Loci in Caenorhabditis elegans.