Oct 16, 2017

Structural insights into processes at DNA damage sites

Ishan Deshpande and his colleagues from the group of Susan Gasser and the Protein Structure Facility at the FMI elucidated the mechanism of how Mec1-Ddc2, a tumor suppressor involved in DNA damage response assembles at sites of DNA damage. They focus on the Ddc2-RPA interaction, which brings the Mec1-Ddc2 kinase complex to single-stranded DNA at sites of DNA damage. With their structural data, the FMI scientists provide the missing link between two previously published structures, allowing them to assemble a to-scale composite structural model of Mec1-Ddc2 on ssDNA-RPA at DNA damage sites Read more

Sep 14, 2017

Predicting what we'll see

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Sep 06, 2017

Three FMI group leaders awarded prestigious European Research Council Grant

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Sep 05, 2017

EMBO at Basel Life, a new conference on current and emerging life science research

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Next seminars & events

Oct 24, 2017. Time: 14:00  FMI Room 530  Add to my calendar  Register for this event

Cell-type specific signals in the basal forebrain
Balazs Hangya, Hungarian Academy of Sciences, Budapest, Hungary

Oct 25, 2017. Time: 13:00  FMI Room 530  Add to my calendar  Register for this event

Genetic dissection of the brainstem REM sleep center
Hayashi Yu, International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan

Oct 25, 2017. Time: 16:00  FMI Room 530  Add to my calendar  Register for this event

Hubert Bloch Lecture
Acute myeloid leukemia: learning from mouse models

Jürg Schwaller, Dept. of Biomedicine, University Hospital Basel

Oct 26, 2017. Time: 11.30  FMI Room 530  Add to my calendar  Register for this event

Shaping the functional structure of the hippocampus
Rosa Cossart, Institut de neurobiology de la méditerranée (Inmed), Marseille, France

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Recent Publications

Miki TS, Carl SH, Großhans H Two distinct transcription termination modes dictated by promoters Genes Dev. 2017 Oct; [Epub ahead of print]

Jeggo PA, Downs JA, Gasser SM Chromatin modifiers and remodellers in DNA repair and signalling Philos Trans R Soc Lond B Biol Sci. 2017 Oct; 372(1731)

Poli J, Gasser SM, Papamichos-Chronakis M The INO80 remodeller in transcription, replication and repair Philos Trans R Soc Lond B Biol Sci. 2017 Oct; 372(1731)

Habacher C, Ciosk R ZC3H12A/MCPIP1/Regnase-1-related endonucleases: An evolutionary perspective on molecular mechanisms and biological functions Bioessays. 2017 Sep; 39(9)

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