Jan 10, 2017

Histone degradation accompanies the DNA repair response

Earlier work from the laboratory of Susan Gasser had noted changes in the physical behavior of chromatin when it incurred DNA damage: loci bearing double-strand breaks showed enhanced movement, becoming highly dynamic. Furthermore, the same effect could be observed with undamaged sites in a cell nucleus responding to DNA damage. Getting to the root cause of this phenomenon, Michael Hauer, a PhD student in her group discovered that histones dissociate from DNA and roughly 30% of the entire complement are degraded upon DNA damage. The process is controlled by the so-called checkpoint response, and the reduction in nucleosome density not only increases DNA mobility but also leads to increased chromatin accessibility for recombination-mediated repair. Read more

Dec 22, 2016

Small RNAs interact with newly synthesized transcripts to silence chromatin

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Dec 05, 2016

Paper from Roska lab among the Best of Neuron 2016

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Nov 18, 2016

Giving the legs a hand: How our limb movements are coupled by long-projecting neurons

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Next seminars & events

Jan 20, 2017. Time: 09.00  FMI Room 530  Add to my calendar  Register for this event

Japan-Swiss Symposium on "Chromatin Structure and Dynamics"
For details and program see attached Flyer
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Jan 23, 2017. Time: 13:30  FMI Room 530  Add to my calendar  Register for this event

Spatio-temporal kinetics of transcription and RNA processing in single cells
Antoine Coulon, Curie Institute, Paris, France.

Jan 23, 2017. Time: 16.00  FMI Room 530  Add to my calendar  Register for this event

Sensory-dependent signaling networks that regulate synapse development and cognitive function
Mike Greenberg, Harvard Medical School, Cambridge, MA, USA
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Jan 30, 2017. Time: 11:00  FMI Room 530  Add to my calendar  Register for this event

Chromatin structure shapes the search process of transcription factors
Nacho Molina, IGMBC Strassbourg, France

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Recent Publications

Ewald CY, Hourihan JM, Bland MS, Obieglo C, Katic I, Moronetti Mazzeo LE, Alcedo J, Blackwell TK, Hynes NE NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans Elife. 2017 Jan; 6:e19493

Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, Voshol H, Vissieres A, Leroy C, Roloff T, Stadler MB, Scheel CH, Miraglia LJ, Orth AP, Bonamy GM, Reddy VA, Bentires-Alj M The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERa Nature. 2017 Jan; [Epub ahead of print]

Hauer MH, Seeber A, Singh V, Thierry R, Sack R, Amitai A, Kryzhanovska M, Eglinger J, Holcman D, Owen-Hughes T, Gasser SM Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates Nat Struct Mol Biol. 2017 Jan; [Epub ahead of print]

Zhan Y, Mariani L, Barozzi I, Schulz EG, Bluthgen N, Stadler M, Tiana G, Giorgetti L Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes Genome Res. 2017 Jan; [Epub ahead of print]

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